Finding order in the inner chaos of our cells: Shape-shifting proteins get a design tool

The vast majority of proteins in our bodies contain regions that are in a constant state of wiggling, shape-shifting every few nanoseconds to completely change how they look. Information on how these shape-shifting proteins work is critical to understanding health and disease and developing drugs for cancer, neurodegeneration and myriad other conditions. However, it has been challenging for scientists to pin down precisely how these regions function and how they go awry in disease.