yay\u0131mlanan<\/a> rastgele kontrol gruplu klinik ara\u015ft\u0131rma, diyabet ve obezite tedavisinde kullan\u0131lan ilac\u0131n alkol ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 \u00fczerindeki etkilerini g\u00f6sterdi.<\/p>\n\u00a0<\/p>\n
Ara\u015ft\u0131rmaya g\u00f6re, a\u011f\u0131zdan al\u0131nan semaglutid etken maddeli ila\u00e7lar, tedavi aray\u0131\u015f\u0131nda olan ve alkol kullan\u0131m bozuklu\u011fu bulunan yeti\u015fkinlerde a\u011f\u0131r alkol t\u00fcketimini, alkol arzusunu ve alkolle ba\u011flant\u0131l\u0131 sorunlar\u0131 azaltt\u0131.<\/p>\n
\u00a0<\/p>\n
Aralar\u0131nda semaglutidin de bulundu\u011fu GLP-1 resept\u00f6r agonistleri, halihaz\u0131rda ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA) taraf\u0131ndan kilo verme ve tip 2 diyabet y\u00f6netimi i\u00e7in onaylanm\u0131\u015f duruma.<\/p>\n
\u00a0<\/p>\n
Giderek artan kan\u0131tlar, zay\u0131flama ve \u015feker hastal\u0131\u011f\u0131 tedavisinde yararlan\u0131lan bu GLP-1 ila\u00e7lar\u0131n\u0131n alkol t\u00fcketimini de etkileyebilece\u011fine i\u015faret ediyor.<\/p>\n
\u00a0<\/p>\n
\u0130kinci faz klinik \u00e7al\u0131\u015fmaya alkol t\u00fcketimini azaltmak veya b\u0131rakmak isteyen, orta ila \u015fiddetli d\u00fczeyde alkol kullan\u0131m bozuklu\u011funa sahip 50 yeti\u015fkin kat\u0131ld\u0131.<\/p>\n
\u00a0<\/p>\n
Kat\u0131l\u0131mc\u0131lar rastgele ayr\u0131larak sekiz hafta boyunca g\u00fcnl\u00fck oral semaglutid veya plasebo alacak gruplara yerle\u015ftirildi.<\/p>\n
\u00a0<\/p>\n
Semaglutid dozu, ilk d\u00f6rt hafta boyunca g\u00fcnde 3 miligram olarak uyguland\u0131ktan sonra kalan d\u00f6rt haftada g\u00fcnde 7 miligrama \u00e7\u0131kar\u0131ld\u0131.<\/p>\n
\u00a0<\/p>\n
A\u011f\u0131zdan al\u0131nan semaglutid, plasebo ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda laboratuvar ortam\u0131nda de\u011ferlendirilen alkol arzusunu veya g\u00fcnl\u00fck i\u00e7ki say\u0131s\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fcrmedi, ancak a\u011f\u0131r alkol al\u0131nan g\u00fcn say\u0131s\u0131n\u0131 belirgin \u015fekilde azaltt\u0131.<\/p>\n
\u00a0<\/p>\n
Plasebo alan kat\u0131l\u0131mc\u0131larla k\u0131yasland\u0131\u011f\u0131nda, semaglutid kullananlar\u0131n tedavinin son d\u00f6rt haftas\u0131nda \u00e7ok daha az say\u0131da a\u011f\u0131r alkol t\u00fcketilen g\u00fcn ge\u00e7irdi\u011fi tespit edildi.\u00a0<\/p>\n
\u00a0<\/p>\n
Bu ki\u015filerin ayr\u0131ca alkol ald\u0131klar\u0131 g\u00fcnlerde daha az i\u00e7ki t\u00fcketti\u011fi, g\u00fcnl\u00fck alkol arzular\u0131nda ve alkol\u00fcn yol a\u00e7t\u0131\u011f\u0131 olumsuz sonu\u00e7larda daha fazla azalma bildirdi\u011fi kaydedildi.<\/p>\n
Colorado \u00dcniversitesi Anschutz T\u0131p Fak\u00fcltesi Psikiyatri Profes\u00f6r\u00fc Dr. Joseph Schacht ara\u015ft\u0131rmaya ili\u015fkin de\u011ferlendirmesinde, “Bu \u00e7al\u0131\u015fma, a\u011f\u0131zdan al\u0131nan semaglutidin, alkol\u00fc tamamen b\u0131rakmaya \u00e7al\u0131\u015fmayan ki\u015filerde dahi a\u011f\u0131r ve zararl\u0131 alkol kullan\u0131m\u0131n\u0131 azaltmaya yard\u0131mc\u0131 olabilece\u011fini g\u00f6steriyor” dedi.<\/p>\n
\u00a0<\/p>\n
Schacht \u015funlar\u0131 ekledi:<\/p>\n
\u00a0<\/p>\n
“Bu \u00f6zellikle mevcut ila\u00e7lardan fayda g\u00f6rmemi\u015f ki\u015filer i\u00e7in alkol kullan\u0131m bozuklu\u011funda yeni bir tedavi se\u00e7ene\u011fini temsil edebilir, alkolle ba\u011flant\u0131l\u0131 sa\u011fl\u0131k sorunlar\u0131n\u0131 ve sosyal zararlar\u0131 azaltabilir. Daha da \u00f6nemlisi, a\u011f\u0131r alkol kullan\u0131m\u0131n\u0131 azaltmak bile hastalar ve aileleri i\u00e7in anlaml\u0131 iyile\u015fmelere yol a\u00e7abilir.”<\/i><\/p>\n
\u00a0<\/p>\n
\u00c7al\u0131\u015fman\u0131n ba\u015flang\u0131c\u0131nda kat\u0131l\u0131mc\u0131lar g\u00fcnde ortalama yakla\u015f\u0131k alt\u0131 kadeh i\u00e7ki t\u00fckettiklerini ve haftada yakla\u015f\u0131k be\u015f g\u00fcn a\u011f\u0131r alkol ald\u0131klar\u0131n\u0131 bildirdi.\u00a0<\/p>\n
\u00a0<\/p>\n
Kat\u0131l\u0131mc\u0131lar\u0131n neredeyse tamam\u0131 D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fcn\u00fcn riskli alkol t\u00fcketimi seviyelerine g\u00f6re y\u00fcksek veya \u00e7ok y\u00fcksek kategoride s\u0131n\u0131fland\u0131r\u0131ld\u0131.<\/p>\n
\u00a0<\/p>\n
Tedavi s\u00fcrecinin sonunda, semaglutid grubundaki kat\u0131l\u0131mc\u0131lar\u0131n y\u00fczde 81’i D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc riskli alkol t\u00fcketimi seviyesini en az bir kategori d\u00fc\u015f\u00fcr\u00fcrken, bu oran plasebo grubunda yakla\u015f\u0131k y\u00fczde 54 seviyesinde kald\u0131.<\/p>\n
\u00c7al\u0131\u015fma \u00f6ncesinde kenevir kulland\u0131\u011f\u0131n\u0131 bildiren 11 ki\u015filik k\u00fc\u00e7\u00fck alt grupta semaglutid kullan\u0131m\u0131, kenevir kullan\u0131lan g\u00fcn say\u0131s\u0131n\u0131n azalmas\u0131yla da ili\u015fkilendirildi. Ara\u015ft\u0131rmac\u0131lar bu bulgunun ke\u015fifsel nitelikte oldu\u011funu vurgulad\u0131.<\/p>\n
\u00a0<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, daha geni\u015f kapsaml\u0131 klinik \u00e7al\u0131\u015fmalar\u0131n yap\u0131lmas\u0131n\u0131n gerekli oldu\u011fu ve semaglutid ile di\u011fer GLP-1RA grubu ila\u00e7lar\u0131n alkol kullan\u0131m bozukluklar\u0131n\u0131n tedavisinde yayg\u0131n kullan\u0131m potansiyeline sahip oldu\u011fu sonucuna vard\u0131.<\/p>\n
\u00a0<\/p>\n
S\u00f6z konusu \u00e7al\u0131\u015fma; ABD Ulusal Alkol Suistimali ve Alkolizm Enstit\u00fcs\u00fc, Ulusal \u0130leri \u00c7evrimsel Bilimler Merkezi, Hewit Family Foundation ve ismini a\u00e7\u0131klamayan bir aile ba\u011f\u0131\u015f\u00e7\u0131s\u0131 taraf\u0131ndan finanse edildi.<\/p>\n
\u00a0<\/p>\n
1844 y\u0131l\u0131nda kurulan Amerikan Psikiyatri Birli\u011fi (APA), ABD’deki en eski t\u0131p derne\u011fi olma niteli\u011fini ta\u015f\u0131yor.<\/p>\n
\u00a0<\/p>\n
Ruhsal hastal\u0131klar\u0131n te\u015fhisi, tedavisi, \u00f6nlenmesi ve ara\u015ft\u0131r\u0131lmas\u0131 alan\u0131nda uzmanla\u015fm\u0131\u015f 40 bin 400’den fazla doktor \u00fcyesi bulunan APA, ayn\u0131 zamanda d\u00fcnyan\u0131n en b\u00fcy\u00fck psikiyatri birli\u011fi konumunda.<\/p>","protected":false},"excerpt":{"rendered":"
American Journal of Psychiatry dergisinde yay\u0131mlanan klinik ara\u015ft\u0131rma, zay\u0131flama ve tip 2 diyabet tedavisinde kullan\u0131lan semaglutid etken maddeli ilac\u0131n alkol kullan\u0131m bozuklu\u011funa da iyi geldi\u011fini ortaya koydu. American Journal of Psychiatry dergisinde yay\u0131mlanan rastgele kontrol gruplu klinik ara\u015ft\u0131rma, diyabet ve obezite tedavisinde kullan\u0131lan ilac\u0131n alkol ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 \u00fczerindeki etkilerini g\u00f6sterdi. \u00a0 Ara\u015ft\u0131rmaya g\u00f6re, a\u011f\u0131zdan al\u0131nan semaglutid …<\/p>","protected":false},"author":1,"featured_media":7238,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-7237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem"],"_links":{"self":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/posts\/7237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/comments?post=7237"}],"version-history":[{"count":0,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/posts\/7237\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/media\/7238"}],"wp:attachment":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/media?parent=7237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/categories?post=7237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/tags?post=7237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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