{"id":5606,"date":"2026-07-29T20:20:06","date_gmt":"2026-07-29T20:20:06","guid":{"rendered":"https:\/\/rdgundem.com\/stable-dna-building-blocks-enable-faster-oligonucleotide-synthesis-without-oxidation\/"},"modified":"2026-07-29T20:20:06","modified_gmt":"2026-07-29T20:20:06","slug":"stable-dna-building-blocks-enable-faster-oligonucleotide-synthesis-without-oxidation","status":"publish","type":"post","link":"https:\/\/rdgundem.com\/en\/stable-dna-building-blocks-enable-faster-oligonucleotide-synthesis-without-oxidation\/","title":{"rendered":"Stable DNA building blocks enable faster oligonucleotide synthesis without oxidation"},"content":{"rendered":"<p>The chemical synthesis of oligonucleotides (ONs) is central to modern molecular biology, diagnostics and nucleic acid therapeutics. While demand for high-quality ONs is increasing, the conventional synthetic method has long-standing efficiency challenges. Widely adopted P(III)-phosphoramidite-based ON synthesis requires an oxidation step after every nucleotide coupling cycle and uses moisture-sensitive building blocks, adding complexity to the workflow and slowing the process.<\/p>","protected":false},"excerpt":{"rendered":"<p>The chemical synthesis of oligonucleotides (ONs) is central to modern molecular biology, diagnostics and nucleic acid therapeutics. While demand for high-quality ONs is increasing, the conventional synthetic method has long-standing efficiency challenges. Widely adopted P(III)-phosphoramidite-based ON synthesis requires an oxidation step after every nucleotide coupling cycle and uses moisture-sensitive building blocks, adding complexity to the &hellip;<\/p>","protected":false},"author":1,"featured_media":5607,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pagelayer_contact_templates":[],"_pagelayer_content":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-5606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem"],"_links":{"self":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/posts\/5606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/comments?post=5606"}],"version-history":[{"count":0,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/posts\/5606\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/media\/5607"}],"wp:attachment":[{"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/media?parent=5606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/categories?post=5606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rdgundem.com\/en\/wp-json\/wp\/v2\/tags?post=5606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}